1131 Microscopic placenta accreta as a risk factor for placenta accreta spectrum in a subsequent pregnancy

The practical significance of microscopic accreta (adherent basal plate myometrial fibers) is unknown, making counseling to affected patients challenging. We hypothesized that (MIP) in a prior pregnancy significant risk factor for placenta spectrum (PAS). Retrospective cohort study subjects who had two consecutive pregnancies delivered at our single hospital, high-volume quartiary care center over the time interval from 2012-2019. All included this analysis (n=1197) underwent detailed placental pathology with boarded pediatric pathologist subspecializing pathology, inclusive gross exam, histology, and cytology and/or vascular mapping as indicated. Patients pathologic diagnosis MIP (exposed/cases; n=197) were compared randomly selected sample 1000 without (unexposed/controls) based on power estimation detect group-wise difference ≥2% 0.8 (80%, p 0.05). Characteristics cases vs controls subsequent index using descriptive statistics. After appropriately adjusting potential confounders, predictive discriminate PAS was evaluated logistic regression calculation adjusted relative (aRR). Comparison against well-recognized clinical factors performed aid counseling. Level set 0.05. are shown Tables. 6/197 (3%) developed their pregnancy. This rate significantly higher than those (10/1000, 1%; p=0.02). crude RR among 3.10 (1.11-8.65; p=0.029) aRR 3.01 (1.08-7.46; p=0.031), 2.91 (1.06-6.83, p=0.040), 2.86 (1.05-6.28, p=0.041) after adjustment number CS, IVF, previa respectively. Our data suggests an independent irrespective other known factors.View Large Image Figure ViewerDownload Hi-res image Download (PPT)